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Advanced Approach To Fat Annihilation!
Researchers are calling the discovery of an exclusive new compound, Beta-Methoxy- Phenylethylamine , a bigger and more promising breakthrough than ephedra and are comparing DREN to Clenbuterol. Scientists have been looking at the basic form Beta-Phenylethyamine (also called Beta-PEA) for years, but unfortunately its short half-life prevented this compound from ever being very effective. The first attempt to overcome the short half-life was to combine Beta-PEA with MAO inhibitors, but this also proved to be not effective. However, this new form isnt just showing promise, its showing amazing results. And while Beta-Methoxy-Phenylethylamine is the new General in the war against fat, a few good soldiers have been added to Dren for total annihilation of stubborn adipose fat!
- The Most Powerful Thermogenic
- So Powerful You Only Need One Capsule
- Exclusive Active Compound-DRENBUTEROL featuring Beta Methoxy-phenylethylamine, Yohimbine HCL, L-5-Hydroxytryptophan
Dren uses an advanced approach to trigger the process of lipolysis for maximum fat burning. Dren (patent pending compound name Drenbuterol) belongs to a powerful new class of compounds called mesolimbic Beta Agonist Fat Burning Agents. Its mechanism of action is similar to that of the popular old ECA (ephedra, caffeine, and aspirin) stack. Plus in addition to extreme thermogenic effects, Dren also has powerful psycho-active euphoric effects.
Step 1: Sympathometic Thermogenic Activation:
Beta-Methoxy Phenylethlyamine (also called Beta-Methoxy PEA) is an exciting new ingredient used exclusively in Dren. Beta-Methox-PEA works in part by increasing noradrenaline (NA) release from sympathetic nerve terminals. As a sympathomimetic, Beta-Methoxy PEA acts to stimulate the sympathetic nervous system. It does this by causing pre-synaptic nerve terminals to release norepinephrine, or what is commonly called noradrenaline (NA), into the synaptic space. It also has the effect of increasing circulating adrenaline, the bodys chief beta-2 agonist. Noradrenaline, once released into the synaptic space, interacts with adrenergic receptors on the surface of adipocytes (fat). This initiates a sequence of events within the adipocyte that increases lipolysis (the breaking down of fatty acids) by the enzyme hormone sensitive lipase (HSL). This fat burning effect is dependent on long and steady activation of the receptor by the agonist and is what makes the discovery of Beta-Methoxy PEA so critical and why it is much more effective than other Beta-PEA Formulas.
Beta-Methoxy PEA is the most effective B-PEA beta-agonist by virtue of its long half-life (stays in the body longer) as well as its affinity to be absorbed in fat tissue and better permeate the blood/brain barrier. In contrast, the half-life of many other Beta-PEA forms is only minutes as the enzyme MAO-B quickly metabolizes them and are less lipophilic which prevents significant concentrations from reaching the brain - therefore no psychoactive and weight loss effect is achieved. As mentioned earlier, while the inclusion of MAO-inhibitors would seem to work the evidence shows otherwise. Beta-Methoxy PEA does not have to worry about being broken down by MAO-B due to its unique configuration. The beta Methoxy moiety on this compound protects it and allows for increased absorption across the blood brain barrier and deep penetration into the fatty tissues of the brain where it interacts with the aDrenergic receptors. This increase in noradrenaline and adrenergic receptors activation increases cAMP levels in fat cells (increasing its breakdown) and muscle cells (increasing protein synthesis). Beta-Methoxy-PEAs unique configuration or moiety is what gives it its long duration of action, its exceptional ability to permeate fat tissue and extremely powerful fat burning effects. I cant emphasize the point enough: its the Methoxy in Beta-Methoxy-PEA that makes it simply unmatched to all other forms of Beta PEA no matter what jargon you read--and its only found in Dren!
In addition, Beta-Methoxy Phenethylamines enhanced moiety and ability to better penetrate the blood brain barrier elicits extreme euphoric feel good neuro-sensory. Beta-Methoxy-PEA, is an alkaloid and monoamine, therefore, it is believed to function as a neuromodulator or neurotransmitter and elicits extreme psychoactive effects on the body while burning body fat at an unforseen rate. To sum it up, Beta-Methoxy Phenethylamine freely enters the brain barrier and triggers a cascading release of norepinephrine, dopamine and serotonin and stimulates the mesolimbic reward pathway, causing euphoria and excitement.
Step 2: The Inclusion of an Alpha 2 Agonist works to further Enhance Beta-Methoxy PEA fat burning!
While Beta-Methoxy-PEA by itself is a remarkably effective thermogenic, the scientists at MHP wanted to take fat burning to a new levels. Lets face it ever since the FDA banned ephedra everyone has been looking for an alternative. MHP wasnt only looking to develop an ephedra alternative we were looking to take it way beyond the ECA stack. Once we isolated Beta-Methoxy-PEA and saw its similar yet superior mechanisms of actions as ephedra we knew we could do it.
In response to Beta-Methoxy-PEAs beta-adrenergic stimulation, negative feedback mechanisms are activated as well. This negative feedback can shutdown lipolysis (fat burning). The alpha 2 receptor, phosphodiesterases and adenosine try to slow down or halt the fat burning process. In the case of Dren, Beta-Methoxy-PEA undergoes these negative feedback mechanisms. Therefore, measures had to be taken to maximize Beta-Methoxy-PEAs actions in the body and minimize these negative feedback mechanisms.
All forms of Beta-PEA are considered non-selective adrenergics through the release of noradrenaline because they dont just active one type of receptor. Unfortunately, noradrenaline functions as its own negative feedback signal by activating both the beta and alpha adrenergic receptors.. As you recall, the stimulation of beta receptors is good as it initiates the fat burning process, but the Alpha 2 receptors actually shut down lipolysis (fat burning). MHP scientists added Yohimbine HCL to the Dren formula to bypass Alpha 2 receptor binding and increases the effectiveness of Dren. Yohimbine HCL is a selective alpha 2 antagonist and can thus short circuit this feedback loop, maximizing noradrenaline levels and the overall fat loss actions of Beta-Methoxy PEA. What we have created is a mechanism of action which is long acting activation on the beta receptor with little to no activity at the alpha receptor. Resulting in the most powerful thermogenic activity in adipose tissue possible.
Step 3: Phosphodiesterase Inhibitibiton and Adenosine Receptor Interferance
Most people like caffeine because of its stimulatory and energizing effects. But, caffeine has a much more important role than that in Dren. Stimulation of Beta-adrenergic receptor also means an increase in phosphodiesterase and adenosine activity. Phosphodiesterase (PDE) acts to hydrolyze cAMP into inactive fragments while adenosine inhibits cAMP accumulation halting the stimulation of HSL and the fat burning process. Caffeine possesses the ability to inhibit phosphodiesterases within the cell and has even been shown to have the ability to prevent some re-uptake of norepinephrine while also acting as an adenosine receptor blocker. As you can see, caffeine provides important powerful synergies to maximize Drens fat burning effects.
Step 4: Powerful Psycho-active Feel Good Neurostimulation
The mind is a powerful thing! Dren will not only transforms your body with the most powerful fat burning thermogenic experience, it will also alter you mind and put you is a place you want to be: On Top of The World. There is no denying it Beta-Methoxy-PEA is very psycho-active and triggers a euphoric feel good response. To further enhance Dren neuromudulator activity L-5-Hydroxytryptophan has also been added to the formula. L-5-Hydroxytryptophan is a naturally-occurring amino acid, a precursor to the neurotransmitter serotonin which is a monoamine neurotransmitter with feel good and appetite suppression properties. L-5-Hydroxtryptophan like Beta-Methoxy-PEA also passes through the blood brain barrier into the brain. Its psychoactive action are thought to be derived from its effect on serotonin synthesis in central nervous system tissue. It is believed that a high supply of L-5-Hydroxytryptophan causes the brain's serotonin-producing neurons to increase production leading to increased serotonin release. The serotoninergic system is known to help modulate mood, emotion, sleep and appetite and thus is implicated in the control of numerous behavioral and physiological functions. L-5-Hydroxytryptophan helps to keep serotonin and norepinephrine levels in balance therefore increasing metabolism and fat loss through synergistic actions with other ingredients in Dren. The end result is an extreme feel good state of euphoria.
The fact is, Dren (Drenbuterol) belongs to a powerful new class of compounds called mesolimbic beta agonist, which have extremely powerful fat burning and euphoric activity and should be taken with caution. Dren stimulates both metabolic and mesolimbic pathways for extreme thermogenic fat burning and neurotropic feel good sensory. Each Dren capsule provides the maximum 470mg dose of Drenbuterol and should only be administered once daily and should not be used with other stimulants. When take as directed, Dren will help potentiate thermogenic fat burning, increase energy levels, suppress appetite and illicit a state of heightened mental euphoria.
Not worth itI don't understand where people get the energy from this that they claim. I bought it when it first came out. Didn't feel a thing. Didn't add anything to my workouts.
Increases energy for a phenomenal workouTakes my workouts to the next level.
Thought I was going to die.Don't ever use this. I couldn't even get out of bed for about 6 hours after I took this. I have taken similar products but never felt like this.
when? would be betterthe product is ok when used directlybefore the gym and the speedy effect last for about first 20 minutes.. no apetite control or perspiration enhancement
a miracle in a little box!A very good product to loose weight but if you want to take a nap in the afetrnoon you better choose another product.
Dren is Amazingi used this product for 3 months and i have to say this product is amazing!!! by far the best fat burner and energy booster on the market today...and as a M.M.A. fighter this product really gave me a boost of energy and adrenalin rush before my fights.
The best product to dateTake 1 pill daily upon waking and that it!! No jitters no shakes you wil be in a great mood no hunger pains helps you loose weight and your workouts are intense so you need nothing extra prior to you workout! Lasts ten hours ! How cool is that! and it effects are just as strong hour ten as they where hour 1!! This is the best!!!
Great StuffTake this everyday for a while and then take a break. You will crash after you get off but it was awesome while I was on it. It is a very effective product and made me feel great. I also got very cut while dieting and using this product.
DRENI was disapointed in this product. I regularly us MHP products and have gotten great results. This however did not meet my expectations. MHP has some great products and I will continue to use them. DREN is new and may need some tweaking.
Gives an energy boostI used this for 30 days. Although I didn't loose weight it did give me an energy boost.