Learn More About Growth Hormone - HGH

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hGH molecule

1. What is Human Growth Hormone And How Can hGH Production Be Increased?

No one is immune from experiencing the signs of aging--slower recovery time, loose skin, aching joints, diminished energy, memory loss, and loss of muscle tone. As our bodies age, our cells and tissues start to deteriorate and regenerate with less fervor.

One of the primary factors of aging is the decreased natural production of human growth hormone. Human growth hormone is responsible for the development and maintenance of lean body mass, bone density and helping to maintain metabolism among other things.

One of the most anabolic hormones around, hGH, or somatotropin, is a peptide hormone (a group of 191 amino acids linked together in a specific sequence released by the anterior pituitary gland throughout the day in pulses).

There are a number of factors which stimulate the release of human growth hormone (hGH) from the anterior pituitary gland, including: sleep, exercise and protein.

Sleep is very important when it comes to the release of human growth hormone. Studies Have shown that GH is secreted in the final stages of a good night's sleep (the first hour or two after reaching deep REM sleep). Unless we get to that deep sound sleep zone, our bodies will not be releasing Growth hormone as efficiently, meaning we lose out on the tissue renewing benefits.

If you are considering human growth hormone stimulating supplements as a means of antiaging, consider that exercise is the most important anti-aging tool in your arsenal. However, not all forms of exercise are created equally. Some workouts are better than others at stimulating growth hormone release.

Studies show that exercise maintained at an intense but not exhaustive level for 15 to 20 minutes works best for hGH release. Examples include a brisk walk, elevating the heart rate or resistance training with weights. One of the best exercises for total body HGH stimulation is squats, simply because it is so intense and because it's a compound movement stimulating many muscle fibers throughout the lift. Moderation is the key here, as too much of anything can be a bad thing. For example, chronic Marathon runners actually show diminished levels of growth hormone.

Naturally, protein consumption is vitalto the body's ability to produce growth hormone because protein is broken down into amino acids, which are then reconstructed into many things including growth hormone. Additionally, specifically designed human growth hormone stimulating supplements of the highest quality can be found at everyday low prices from A1Supplements.com!

2. What do Human Growth Hormone Stimulating Supplements do and what scientific studies give evidence to support this?

Growth hormone related sports supplements work in synergy to accelerate muscle growth and recovery without the adverse side effects normally attributed to illegal anabolics. Faster muscle recovery means faster, easier muscle growth. For those individuals who have difficulty putting on mass, hGH supplements stimulate appetite and aid the body in nutrient absorption.

Growth hormone supplements may:

  • Increased muscle tone
  • Decrease in body fat
  • Increased energy, endurance and stamina
  • Restoration of hair color, healthier and thicker hair
  • Reduced appearance of wrinkles, skin elasticity and tighter skin tone
  • Mood elevation
  • Improved and deeper sleep
  • Improved sex drive in both men and women
  • Normalized blood pressure
  • Improved cholesterol profile: decreased LDL cholesterol and increased HDL cholesterol
  • Improved vision
  • Improvement in memory and mental alertness
  • Improved immune function

Some of the common growth hormone stimulating supplements include:

  • Mucuna pruriens - commonly knows as velvet bean, contains L-Dopa
  • Alpha GPC - soy derived substance that interacts with the neurotransmitter acetylcholine
  • Bacopa - an herb which plays an indirect but supportive role in helping to build new neurons (nerve/brain cells)
  • GABA, Gamma Aminobutyric Acid - an amino acid classified as a neurotransmitter

All about GABA:

GABA, Gamma Aminobutyric Acid, is an amino acid classified as a neurotransmitter (A neurotransmitter is a substance that transmits nerve impulses across a synapse. A synapse is a region where nerve impulses are transmitted across axon terminals.)

GABA's high concentration in the hypothalamus suggests this amino acid plays a significant role in hypothalamic-pituitary function. The hypothalamus is a region of the posterior section of the brain and is the regulating center for visceral (instinctive) functions such as sleep cycles, body temperature, and the activity of the pituitary gland.

The pituitary gland is the master endocrine gland affecting all hormonal functions of the body. One primary hormone of concern to the athlete is growth hormone (GH) and its various hormonal constituents.

The amino acid GABA has been shown in numerous studies to promote significant increases in plasma growth hormone levels.

There have been literally hundreds of clinical studies on GABA and numerous studies on GABA's ability to elevate growth hormone levels. As with most nutritional studies, GABA research has come directly from the medical community. One noted study from the First Medical Clinic at the University of Milan in Milan, Italy titled, "Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man", shows just how effective GABA is.

Quoted results from this study showed "In all of the 19 subjects studied, compared with 18 controls, plasma growth hormone levels were significantly increased (above 5 ng/ml) by acute oral administration of 5 g of GABA."

This study showed over a 5 1/2 fold increase in plasma growth hormone levels 90 minutes after GABA administration. That is a significant increase unmatched by any other nutritional means.

Most cited studies on amino acids and growth hormone elevation utilize intravenous delivery means. This is unrealistic and doesn't reflect real world results. Studies on GABA have been performed with both oral and intravenous administration with the oral route showing remarkable effectiveness.

GABA's growth hormone elevating effects rival that of potent pharmaceutical compounds.

3. Who needs Human Growth Hormone Stimulating Supplements and how much should be taken? Are there any side effects or symptoms of deficiency?

Growth hormone supplements may dramatically strengthen connective tissue including ligaments and tendons, which is of particular interest to all of us who are aging, as well as athletes and bodybuilders. Stronger connective tissue leads to more strength. Other benefits derived from hGH products include healthy muscle and joint support, increased energy and stamina, and greater concentration and focus.

We always suggest taking the recommended dosage on the bottle of whatever product it is you are taking. Never take more than the recommended dosage.

Children under the age of 18 should not take hGH supplements and anyone else should always consult with their doctor if they have any specific questions about the negative possibilites that a certain supplement could have on them. To date, there has not been a significant study done to determine if there are any side effects to taking hGH supplements as recommended.

Side effects from "real" hGH injections from the doctor's office in adults may include fluid retention, joint pain, and nerve compression symptoms. There is possibility that GH treatment may increase the risks of diabetes or cancer, especially in those with other predispositions treated with higher doses, but this has yet to be proven. Diabetes, for example, is a disease that develops over perhaps 30 or 40 years of poor eating habits, and the most likely cause of diabetes is the poor nutrition which the patient had prior to the use of growth hormone.

Generally speaking, enhancing your body's natural growth hormone production is regarded is a healthier way to elevate hGH than GH treatments.

Published with permission, original © 2007.

References:

http://en.wikipedia.org/wiki/Growth_hormone
Alba-Roth J, Müller O, Schopohl J, von Werder K (1988). "Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion". J Clin Endocrinol Metab 67 (6): 1186-9.
Involvement of growth hormone-releasing factor in growth hormone secretion induced by gamma-aminobutyric acid in conscious rats. Murakami Y, 1985 Endocrinology 117(2), 787-789 (1985)
Evidence for a GABAergic control of the exercise-induced rise in GH in man. Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Eur J Clin Pharmacol 28 (5): 607-609 (1985)
Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro. Acs Z, Makara GB, Stark E Life Sci 34 (16): 1505-1511 (Apr 1984)
Gamma aminobutyric acid (GABA), a modulator of anterior pituitary hormone secretion by hypothalamic and pituitary action. McCann SM, Vijayan E, Negro-Vilar A, Mizunuma H, Mangat H Psychoneuroendocrinology 9 (2): 97-106 (1984)
Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone. Cavagnini F, Benetti G, Invitti C, Ramella G, Pinto M, Lazza M, Dubini A, Marelli A, Muller EE J Clin Endocrinol Metab 51 (4): 789-792 (Oct 1980)
Effects of some gamma-aminobutyric acid (GABA)-ergic drugs on the dopaminergic control of human growth hormone secretion. Koulu M, Lammintausta R, Dahlstrom S J Clin Endocrinol Metab 51 (1): 124-129 (Jul 1980)
Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Cavagnini F, Invitti C, Pinto M, Maraschini C, Di Landro A, Dubini A, Marelli A Acta Endocrinol (Copenh) 93 (2): 149-154 (Feb 1980)
"A single oral dose of 5 g gamma aminobutyric acid (GABA) was given to 19 subjects and serial venous blood samples were obtained before and 3 h after drug administration. A placebo was administered to 18 subjects who served as controls. GABA caused a significant elevation of plasma growth hormone levels (P less than 0.001), but did not consistently alter plasma prolactin concentration since only 5 out of 15 subjects showed an increase of the hormone. Eight additional subjects were submitted to an insulin tolerance test before and after per os administration of 18 g GABA daily for 4 days. Protracted GABA treatment significantly blunted the response of growth hormone and enhanced that of prolactin to insulin hypoglycaemia (P less than 0.01). These results indicate that pharmacological doses of GABA affect growth hormone and prolactin secretion in man. The precise nature of GABA's effects as well as its mechanism of action remains to be clarified."
Growth hormone release by gamma-aminobutyric acid (GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB) in the rat. Abe H, Kato Y, Chihara K, Ohgo S, Iwasaki YEndocrinol Jpn 24 (2): 229-231 (Apr 1977)
Regulation of growth hormone secretion Kato Y, Chihara K, Daigo S, Iwasaki Y, Abe H Horumon To Rinsho 25 (2): 131-141 (Feb 1977)
Pharmacological evidence for a dual GABAergic regulation of growth hormone release in humans. Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Life Sci 39 (11): 979-985 (Sep 1986)
Involvement of alpha-adrenergic and GABAergic mechanisms in growth hormone secretion induced by central somatostatin in rats. Murakami Y, Kato Y, Koshiyama H, Inoue T, Ishikawa Y, Imura H Brain Res 407 (2): 405-408 (Mar 1987)
Evidence for a sex difference in the basal growth hormone response to GABAergic stimulation in humans. Monteleone P, Maj M, Iovino M, Steardo L Acta Endocrinol (Copenh) 119 (3): 353-357 (Nov 1988)
Role of hypothalamic factors (growth-hormone-releasing hormone and gamma-aminobutyric acid) in the regulation of growth hormone secretion in the neonatal and adult rat. Acs Z, Lonart G, Makara GB Neuroendocrinology 52 (2): 156-160 (Aug 1990)
Possible mediation of GABA induced growth hormone secretion by increased calcium-flux in neonatal pituitaries. Acs Z, Zsom L, Makara GB Life Sci 50 (4): 273-279 (1992)
Potent agonists of growth hormone-releasing hormone. II. Zarandi M, Serfozo P, Zsigo J, Deutch AH, Janaky T, Olsen DB, Bajusz S, Schally AV Pept Res 5 (4): 190-193 (Jul 1992)
New Gaba-containing analogues of human growth hormone-releasing hormone (1-30)-amide: I. Synthesis and in vitro biological activity. Mezo I, Kovacs M, Szoke B, Szabo EZ, Horvath J, Makara GB, Rappay G, Tamas J, Teplan I J Endocrinol Invest 16 (10): 793-798 (Nov 1993)
Neuroendocrine regulation of growth hormone secretion in sheep. VII. Effects of GABA. Spencer GS, Berry CJ, Bass JJ Regul Pept 52 (3): 181-186 (Aug 1994)
Growth hormone secretion and activation of cyclic AMP by growth hormone releasing hormone and gamma-aminobutyric acid in the neonatal rat pituitary. Mergl Z, Acs Z, Makara GB Life Sci 56 (8): 579-585 (1995)

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