I have had a total Thyroidectomy after having been diagnosed with Thyroid cancer 4 years ago. I have been on various doses of Synthroid since, but have gained 20 lbs and have had decreasing energy. I cannot find a doctor who can help...they all say my numbers are fine and to eat less. I cut my calories down to 900 a day and worked out and lost a whole 1/2 lb. Then I began reading up on reverse T3 and decided to experiment. It took about 3 days taking 4/day to notice that I no longer needed a nap after work. After a week I was looking around the house for things to do, something I hadn't had the energy to worry about in a couple of years. My quality of life is improving greatly, I can honestly say. I have had zero side effects from them so far. This is my 3rd bottle and I am very pleased with the results. I lost 4 lbs in the first few weeks of taking them also, without even watching what I ate.