Drink it with milk in recommended dose half an hour before sleep and work out in the morning. Work out either in morning or at least in the evening seems to be a must when taking this supplement, otherwise it causes severe headache especially when the GH is released in pulsatile fashion. Other long-term side effects are not clearly known, so it is better to be off this after a month or so to get rid of the excess GABA from the system. These kinds of supplements are good to change the stagnant equilibrium of the hormones but the new dynamic balance needs to established through proper work out and diet.